解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In the article (Romek et al. 2013) we reported the values of δ15N (‰) and δ13C (‰) obtained by. ...
journal_title:Amino acids
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00726-017-2506-2
更新日期:2018-01-01 00:00:00
abstract::Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2487-1
更新日期:2018-01-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2471-9
更新日期:2017-10-01 00:00:00
abstract::A novel type I ribosome-inactivating protein (RIP), designated as curcin C, was purified from Jatropha curcas, an important feedback source of bio-fuel. Molecular mass and isoelectric point of curcin C were 31.398 kDa and 7.12 as detected by MALTI-TOF assay and capillary electrophoresis assay, respectively. N-terminal...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2456-8
更新日期:2017-09-01 00:00:00
abstract::This work proposes a strategy that uses solid-phase peptide synthesis associated with copper(I)-catalyzed azide alkyne cycloaddition reaction to promote the glycosylation of an antimicrobial peptide (HSP1) containing a carboxyamidated C-terminus (HSP1-NH2). Two glycotriazole-peptides, namely [p-Glc-trz-G1]HSP1-NH2 and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2441-2
更新日期:2017-08-01 00:00:00
abstract::Effects exerted by heavy isotope substitution in biopolymers on the functioning of whole organisms have not been investigated. We report on the decrease of permissive temperature of nematodes fed with bacteria containing 5,5-D2-lysine. We synthesized 5,5-dideuterolysine and, taking advantage of lysine being an essenti...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2386-5
更新日期:2017-05-01 00:00:00
abstract::A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2375-0
更新日期:2017-04-01 00:00:00
abstract::Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2360-7
更新日期:2017-02-01 00:00:00
abstract::A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2364-3
更新日期:2017-02-01 00:00:00
abstract::Fibrosis, closely related to chronic various diseases, is a pathological process characterised by the accumulation of collagen (largely collagen type I). Non-invasive methods are necessary for the diagnosis and follow-up of fibrosis. This study aimed to develop a collagen-targeted probe for the molecular imaging of fi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2328-7
更新日期:2017-01-01 00:00:00
abstract::Functionalized collagen-mimetic peptides (CMPs) have been widely used in the preparation of collagen-related biomaterials. Among the reported results, the induced noncovalent interactions between the implanted functional groups or moieties were frequently the key elements to promote the self-assembly of small CMPs. In...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2312-2
更新日期:2016-12-01 00:00:00
abstract::This study investigated the effect of taurine and β-alanine supplementation on muscle function and muscle taurine transporter (TauT) protein expression in mdx mice. Wild-type (WT) and mdx mice (5 months) were supplemented with taurine or β-alanine for 4 weeks, after which in vitro contractile properties, fatigue resis...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2292-2
更新日期:2016-11-01 00:00:00
abstract::Taurine (TAU) has been shown to improve exercise time to exhaustion and 3-km running performance; however, no studies have considered the effect of acute TAU ingestion on short duration cycling time trial (TT) performance. The aim of this study was to determine the effects of a single oral acute dose of 1000 mg of TAU...
journal_title:Amino acids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00726-016-2282-4
更新日期:2016-11-01 00:00:00
abstract::The translation elongation factor eIF5A is conserved through evolution and is necessary to rescue the ribosome during translation elongation of polyproline-containing proteins. Although the site of eIF5A binding to the ribosome is known, no systematic analysis has been performed so far to determine the important resid...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2279-z
更新日期:2016-10-01 00:00:00
abstract::Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2256-6
更新日期:2016-10-01 00:00:00
abstract::Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthetized and tested for their action against amnesia induced by eletroconvu...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2268-2
更新日期:2016-09-01 00:00:00
abstract::Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2183-6
更新日期:2016-08-01 00:00:00
abstract::The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via su...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2188-1
更新日期:2016-08-01 00:00:00
abstract::Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biase...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2236-x
更新日期:2016-08-01 00:00:00
abstract::A species of the poorly studied order Embioptera, the webspinner Oligotoma saundersii, is investigated for its complement of neuropeptides of the adipokinetic hormone (AKH) family. A methanolic extract of its corpora cardiaca (CC) is able to effect carbohydrate mobilization in the cockroach, Periplaneta americana, and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2229-9
更新日期:2016-07-01 00:00:00
abstract::D-Aspartate (D-Asp) is a free D-amino acid detected in multiple brain regions and putative precursor of endogenous N-methyl-D-aspartate (NMDA) acting as agonist at NMDA receptors. In this study, we investigated whether D-Asp (20 mM) in drinking solution for 1 month affects pain responses and pain-related emotional, an...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2205-4
更新日期:2016-07-01 00:00:00
abstract::Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2201-8
更新日期:2016-06-01 00:00:00
abstract::Nitrogen fixation of the nodule of soybean is highly sensitive to oxygen deficiency such as provoked by waterlogging of the root system. This study aimed to evaluate the effects of flooding on N metabolism in nodules of soybean. Flooding resulted in a marked decrease of asparagine (the most abundant amino acid) and a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2179-2
更新日期:2016-05-01 00:00:00
abstract::Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnos...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2208-1
更新日期:2016-05-01 00:00:00
abstract::Enzymes are the most versatile molecules in the biological world. These amazing molecules play an integral role in the regulation of various metabolic pathways and physiology subsequently. Promiscuity of an enzyme is the capacity to catalyze additional biochemical reactions besides their native one. Catalytic promiscu...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-2162-3
更新日期:2016-04-01 00:00:00
abstract::The interaction of antitumor drug, cisplatin (cis-[PtCl2(NH3)2], CDDP) with insulin from porcine pancreas has been investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high resolution hybrid ion trap/time-of-flight mass spectrometry (MALIDI-TOF/TOF-MS and ESI-IT/TOF MS). The...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2159-y
更新日期:2016-04-01 00:00:00
abstract::Low concentrations of L-homoarginine (hArg) in plasma or serum and urine have recently emerged as a novel cardiovascular risk factor. Previously, we reported gas chromatography-mass spectrometry (GC-MS) and GC-tandem MS (GC-MS/MS) methods for the quantitative determination of hArg and Arg in plasma, serum, urine and o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2120-0
更新日期:2016-03-01 00:00:00
abstract::Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship bet...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2134-7
更新日期:2016-03-01 00:00:00
abstract::Taurine is a β-amino acid found in high concentrations in excitable tissues, including the heart. A significant reduction in myocardial taurine content leads to the development of a unique dilated, atrophic cardiomyopathy. One of the major functions of taurine in the heart is the regulation of the respiratory chain. H...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2110-2
更新日期:2016-02-01 00:00:00
abstract::In mammals, two major routes exist for the metabolic conversion of L-glutamine to α-ketoglutarate. The most widely studied pathway involves the hydrolysis of L-glutamine to L-glutamate catalyzed by glutaminases, followed by the conversion of L-glutamate to α-ketoglutarate by the action of an L-glutamate-linked aminotr...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-2061-7
更新日期:2016-01-01 00:00:00
abstract::Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2053-7
更新日期:2015-12-01 00:00:00
abstract::In this paper, nanoparticles of Fe3O4 as well as their modified forms with different ionic liquids (IL-Fe3O4) were prepared and used for adsorption of lysozyme. The mean size and the surface morphology of the nanoparticles were characterized by TEM, XRD and FTIR techniques. Adsorption studies of lysozyme were performe...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2033-y
更新日期:2015-12-01 00:00:00
abstract::Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2029-7
更新日期:2015-11-01 00:00:00
abstract::The hydration of selected amino acids, alanine, glycine, proline, valine, isoleucine and phenylalanine, has been studied in aqueous solutions by means of FTIR spectra of HDO isotopically diluted in H2O. The difference spectra procedure and the chemometric method have been applied to remove the contribution of bulk wat...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2005-2
更新日期:2015-11-01 00:00:00
abstract::Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site. We demonstrate that the enzyme binds α-keto acids, such as pyruvate, in solution, and catalyzes the formation of N-alkyl-amino acids from alkylamines and α-keto acids (via reduction of imine in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2044-8
更新日期:2015-11-01 00:00:00
abstract::Branched Chain Amino Acids (BCAAs) are related to different aspects of diseases like pathogenesis, diagnosis and even prognosis. While in some diseases, levels of all the BCAAs are perturbed; in some cases, perturbation occurs in one or two while the rest remain unaltered. In case of ischemic heart disease, there is a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1994-1
更新日期:2015-10-01 00:00:00
abstract::Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors. However, there are discordant reports on the effects of metformin on endothelial function in T2DM. Our ...
journal_title:Amino acids
pub_type: 临床试验,杂志文章
doi:10.1007/s00726-015-1976-3
更新日期:2015-09-01 00:00:00
abstract::L-Homoarginine is a cationic amino acid derivative, which is structurally related to L-arginine and lysine. Several lines of evidence point to nervous tissue as an important target of homoarginine action. In the mammalian brain homoarginine can be detected in noticeable quantities, but its origin is currently poorly e...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-1960-y
更新日期:2015-09-01 00:00:00
abstract::Hyperargininemia is caused by deficiency of arginase 1, which catalyzes the hydrolysis of L-arginine to urea as the final enzyme in the urea cycle. In contrast to other urea cycle defects, arginase 1 deficiency usually does not cause catastrophic neonatal hyperammonemia but rather presents with progressive neurologica...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-2032-z
更新日期:2015-09-01 00:00:00
abstract::Among the available protocols, chemically driven approaches to oxidize cysteine may not be required for molecules that, under the native-like conditions, naturally fold in conformations ensuring an effective pairing of the right disulfide bridge pattern. In this contest, we successfully prepared the distinctin, a natu...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1983-4
更新日期:2015-08-01 00:00:00